Am J Pharmacol | Volume 7, Issue 1 | Research Article | Open Access
Fakoya A, Ishola AA and Olusola AO*
Department of Biochemistry, Adekunle Ajasin University, Akungba Akoko, Ondo, Nigeria
*Correspondance to: Olusola AO
Fulltext PDFEbola Virus (EBOV) is a single-stranded, negative-sense RNA virus that causes severe hemorrhagic in humans and non-human primate. It is a virus not receptive to a large portion of known antiviral drugs, and there is no valid treatment for the disease up till now. Looking at the ability of Ebola virus to create a pandemic scenario across globe; there is a paramount need for new drugs and therapeutics to fight this life-threatening infection. This research work dealt with the evaluation of the inhibitory activity of some purified phytochemicals of Buchholzia coriacea against five randomly selected Ebola virus receptor proteins, using in-silico studies. The viral proteins: Nucleoprotein, Glycoprotein, VP35, VP30 and RNA polymerase L were docked with the lead compounds obtained from the phytochemicals of B. coriacea; catechin, limonene, taraxerone, nobiletin and kaempferol-3,7,4'-trimethyl ether. The results showed that ligands; catechin, kaempferol-3,7,4'- trimethyl ether and nobiletin, showed better inhibitory potentials on all the EBOV receptors except on Nucleoprotein receptor when compared with that of the standard compounds. Hence, all the screened ligands that exhibited high potential inhibitory properties can be taken as anti-Ebola drug without delay for clinical trials.
Hemorrhagic; Ligands: Pharmacokinetic; Inhibitory; Phytochemicals; In-silico
Fakoya A, Ishola AA, Olusola AO. In-Silico Studies on the Inhibitory Potentials of Some Phytochemicals of Buccholzia coriacea against Selected Ebola Virus Receptor Proteins. Am J Pharmacol. 2024; 7(1): 1038..