World J Breast Cancer Res | Volume 4, Issue 1 | Review Article | Open Access

Elucidating the Clinical-Pathological Factors and Prognosis in Breast Cancer Young Surviving Women who had a Subsequent Pregnant

Ramírez-Torres Nicolás1*, Hernández-Valencia Marcelino2 and Rivas-Ruíz Rodolfo3

1Service of Oncological Gynecology, UMAE del Hospital de Ginecología y Obstetricia No. 3, National Medical Center (CMN) La Raza, Mexican Institute of Social Security (IMSS), Mexico 2Unit of Medical Research in Endocrine Diseases, Hospital de Especialidades, CMN SXXI, IMSS, Mexico 3Clinical Research Training Center (CAIC), CMN SXXI, IMSS, Mexico

*Correspondance to: Ramírez-Torres Nicolás 

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Objective: To elucidate the impact of clinical-pathological factors on Overall Survival (OS) in patients who got pregnant after breast cancer treatment. Methods: Retrospective cohort of women age younger than 40 years with breast cancer history without active disease at diagnosis of pos cancer pregnancy. Clinical-pathological factors were analyzed by age group and recent birth. Overall Survival (OS) was evaluated from Kaplan-Meier method. The association between clinical-pathological factors and OS was examined using Cox proportional hazards method to estimate Hazard Ratio (HR) with 95% Confidence Intervals (CI). Results: A total of 14 patients were selected. Median age was 28.5 years (inter quartile range, 26-35). Locally advanced stage (IIB-IIIB) was diagnosed in 64.3%. Patients lower than 35 years experienced more positive clinical lymph nodes (72.7%), grade 2 (63.6%) and ER/Pg R-negative tumors (54.5% and 72.7%, respectively). The patients with ER-positive tumors showed an improvement nonsignificant at 5-year OS (87%; p=0.097). In the bivariate analysis, patients with a higher number of pathological lymph nodes (pNs) had a 12% increase in the risk of death than those with lower number (HR=1.12; 95% CI: 1.02 to 1.2). The multivariate model (after adjustment for number of pNs, age and tumor size) as certained that the nodal status was the only independent predictor associated to a worse OS (HR=1.15; 95% CI: 1.01 to 1.3). Conclusion: Pregnancy after cancer did not have a detrimental effect on survival. The patients <35 years old group showed more unfavorable tumor features at diagnosis, which can largely explain a poorer prognosis. Nodal status was the most important prognostic factor that predicted the poor prognosis.


Breast cancer; Young age; Subsequent pregnancy; Postpartum period; Surviving


Nicolás R-T, Marcelino H-V, Rodolfo R-R. Elucidating the Clinical- Pathological Factors and Prognosis in Breast Cancer Young Surviving Women who had a Subsequent Pregnant. World J Breast Cancer Res. 2021;4(1):1022..

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