Uy TGC*, Alcala GRM, Bocobo JC, Bingcang CLA, Pascual-Panganiban AMM, EvangelistaGorospe AS, Panganiban JZK and Imasa MSB
Department of Medicine, St. Luke’s Medical Center, PhilippinesFulltext PDF
Introduction: Rhabdomyosarcoma (RMS) of the prostate in young adults is exceedingly rare.
Case Report: A 27-year-old male presented with 2-month history of lower urinary tract symptoms. Prostate was enlarged smooth nontender with no nodularity’s. PET-CT showed prominent iliac chain lymph nodes, enlarged spleen and multiple osseous lytic and blastic lesions. Histopathology of prostate tissues revealed round cell malignancy, positive for Desmin and Myogenin. Archer analysis was positive for PAX3:FOXO1 fusion gene. Patient was diagnosed as Alveolar Rhabdomyosarcoma of the prostate Stage IVB (cT4N1M1B-bone). He underwent Vincristine, Dactinomycin and Cyclophosphamide (VAC) chemotherapy.
Conclusion: Prostatomegaly and splenomegaly are unusual findings in a young male. A high index of suspicion will help in detecting prostatic malignancy before it is too late
Lower urinary tract symptoms; Prostate cancer; Rhabdomyosarcoma
Uy TGC, Alcala GRM, Bocobo JC, Bingcang CLA, Pascual-Panganiban AMM, Evangelista-Gorospe AS, et al. Alveolar Rhabdomyosarcoma of the Prostate Presenting as Lower Urinary Tract Symptoms in a Young Adult. Oncol Case Report J. 2023; 6(2): 1056..