Oncol Case Rep J | Volume 7, Issue 1 | Case Series | Open Access
Meschede J1, Kunze M1, Bertz H2, Juhasz-Boess I1 and Markfeld-Erol F1*
1Department of Obstetrics and Gynecology, University of Freiburg Medical Center, Germany 2Division of Hematology, Oncology and Stem Cell Transplantation, University of Freiburg Medical Center, Germany
*Correspondance to: Filiz Markfeld Erol
Fulltext PDFThere is a clear need for more experience in the treatment of pregnant patients with metastatic gastrointestinal cancer. We present our experiences with two women diagnosed with metastatic disease during pregnancy. A 29-year-old I/O was diagnosed with metastatic colorectal cancer in the 12th week of pregnancy. She underwent systemic therapy with FOLFOX (oxaliplatin/5-fluorouracil) in the second trimester because of a high tumor burden. The treatment improved her general condition significantly. She delivered a healthy boy at 36 weeks of gestation. The second case is as follows: A 32-year-old I/O suffered from advanced gastric carcinoma and was diagnosed in the second trimester. She received FOLFOX, which was initiated in the 22nd week of pregnancy. She delivered a healthy girl in the 36th week via emergency caesarean section due to an abruptio placenta during labor. The management of cancer in pregnant women is challenging and requires a multidisciplinary approach. We conducted a thorough review of the literature before initiating the treatment. The purpose of this article is to provide a brief overview of the current data for FOLFOX chemotherapy in pregnancy.
Metastatic colorectal cancer; Pregnancy; FOLFOX; Chemotherapy
Meschede J, Kunze M, Bertz H, Juhasz-Boess I, Markfeld-Erol F. Systemic Treatment of Metastatic Gastrointestinal Cancer in Pregnancy - Two Case Reports and A Short Review. Oncol Case Report J. 2024; 7(1): 1063.