Oncol Case Rep J | Volume 7, Issue 1 | Case Report | Open Access

Secondary Cutaneous Diffuse Large B-Cell Lymphoma: A Rare Presentation with Systemic Implications

Arévalo-Ortega I^*, Martínez-Peña N, Lobato-Izagirre A, Gainza Apraiz I, Sánchez Diez A, and Izu-Belloso R

Department of Dermatology, Hospital Universitario Basurto, Spain

^*Correspondance to: Irene Arévalo Ortega 

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Abstract

Background: Diffuse Large B Cell Lymphoma (DLBCL) is the most prevalent form of non-Hodgkin’s lymphoma, comprising 25% to 30% of cases. DLBCL typically manifests as new tumors in lymph nodes or other areas, notably axillary and abdominal regions. However, in about one third of cases, DLBCL initially affects extranodal organs, commonly the gastrointestinal tract, and occasionally involving the skin, presenting with features resembling other dermatological conditions, posing challenges to diagnosis.
Case Report: This article presents a case of a 69-year-old man that consulted for a scapular lesion that was misdiagnosed as an infected epidermal cyst and subsequently developed a scapular ulcerated lesion. Pathological analysis revealed extensive dermal infiltration by a diffuse lymphoproliferative lesion. Immunohistochemical analysis confirmed the diagnosis of DLBCL with BCL6 rearrangement. Further imaging studies revealed systemic involvement and the final diagnosis was DLBCL, activated cell subtype. The patient responded well to R-CHOP chemotherapy, achieving a complete response within four months.
Conclusion: We describe a case of systemic DLBCL initially presenting as a solitary skin lesion in which histological examination confirmed DLBCL diagnosis. We would like to emphasize the need for a comprehensive evaluation in atypical dermatological cases and the importance of considering rare cutaneous presentations of systemic lymphomas and conducting a thorough diagnostic workup to ensure proper treatment.

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Citation:

Arévalo-Ortega I, Martínez-Peña N, Lobato-Izagirre A, Gainza Apraiz I, Sánchez Diez A, Izu-Belloso R. Secondary Cutaneous Diffuse Large B-Cell Lymphoma: A Rare Presentation with Systemic Implications. Oncol Case Report J. 2024; 7(1): 1062..