Neurol Case Rep | Volume 7, Issue 1 | Case Report | Open Access

Seizure Freedom Without Seizure Medication Following Stereoelectroencephalography Implantation: A Case Report of Drug-Resistant Post-Traumatic Epilepsy

Tran A* and Bunch M

Albany Medical Center 43 New Scotland Ave, USA

*Correspondance to: Alexander Tran 

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Background: Achieving seizure freedom following failure of several Antiseizure Medications (ASMs) is rare, with the likelihood of achieving further control decreasing with each successive ASM trial. When cases of drug-resistant epilepsy arise, a diagnostic procedure known as Stereoelectroencephalography (sEEG) can be used to identify Epileptogenic Zones (EZ) within the brain. After localization of these zones, they can be targeted for future surgical intervention. Here, we describe a case of complete seizure freedom off medication after stereo EEG without resection or other therapeutic intervention. Case Report: In 2017, a 36-year-old right-handed male presented with drug-resistant epilepsy stemming from prior traumatic brain injury. Typical seizures were described as a behavioral arrest with oral automatisms or automatic speech, head and eye deviation to the left, sometimes preceded by olfactory aura of smoke with rare progression to bilateral tonic-clonic seizures. Nine typical seizures and one subclinical seizure were captured during video EEG and showed regional right temporal onset. Interictal EEG showed right temporal epileptiform discharges and focal slowing. Due to ongoing drug resistance, in 2020 a robotic-assisted sEEG electrode placement procedure was employed to localize the seizure onset zone. The patient underwent a 13-day video sEEG monitoring study with the goal of localizing the seizure onset zone for potential surgical resection. During sEEG monitoring, a single clinical event was captured where the patient had dysarthric speech, left arm dystonic flexion, and difficulty responding to questioning. Notably, this event had no sEEG correlate, suggesting seizure occurrence in a region not monitored by implanted electrodes, which prompted the placement of scalp electrodes following this event. However, no further clinical events consistent with seizure were provoked through the remainder of recording. Following the 13-day admission, the patient chose to self-discontinue all seizure medications and has remained seizure free as of October 2023, more than 3.5 years later. Conclusion: While sEEG is considered a relatively safe procedure for seizure localization in drug resistant epilepsy, the possibility of microlesions created by sEEG depth electrodes remains largely unexplored. Further evaluation should be performed into potential tissue injury produced by depth electrode insertion.


Stereoelectroencephalography; Drug-resistant epilepsy; Intracranial electrodes; Microlesion effects


Tran A, Bunch M. Seizure Freedom Without Seizure Medication Following Stereoelectroencephalography Implantation: A Case Report of Drug- Resistant Post-Traumatic Epilepsy. Neurol Case Rep. 2024; 7(1): 1044..

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