J Pharmacol Pharmacother | Volume 1, Issue 1 | Review Article | Open Access
Michel Bourin
Neurobiology of Anxiety and Mood Disorders, University of Nantes, France
*Correspondance to: Michel Bourin
Fulltext PDFThe growing increase in the consumption of illicit products (heroin, cocaine, ecstasy), addiction and problems with withdrawal linked to the administration of substances acting at the central level (benzodiazepines, antidepressants, barbiturates, etc.) require early management of addictive activity of molecules. The acquisition of behavior self-administration was then studied as an animal model initiation of addiction and the resumption of this behavior after its extinction as an animal model of relapse or "Craving". In fact, the discovery of rewarding effects of drugs in non-dependent animals does not have not just relegated addiction physics in the background in the definition of addiction but it’s also contributed to elude conceptions and descriptions psychiatric the notion of "individual personalities vulnerable”. For the first time, the experimenters - mainly neurobiologists - sought to develop new theories of addiction based mainly on knowledge of neurobiological substrates rewarding effects drugs. Knowledge of neuronal mechanisms and structures involved in these phenomena in animals is of great benefit in terms of research strategy, and makes it possible to guide the choice of criteria for evaluating possible drug dependence in clinical trials. Reliable and reproducible animal models, allowing rapid detection of drug dependencies during development should be implemented.
Drug self-administration; Face validity; Predictive validity; Animal models; Drug addiction; Withdrawal; Substitution
Bourin M. Animal Models of Addiction. J Pharmacol Pharm. 2024; 1(1): 1003..