J Hematol Mult Myeloma | Volume 3, Issue 1 | Research Article | Open Access

Role of Epstein Barr Virus in the Attack of Malignant Lymphoma

Changkai Zhang¹, Xiaofang Guo¹, Jie Yang² and Hongzai Guan^1*

¹Department of Hematology, Qingdao University Medical College, China
²Department of Hematology, Affiliated Hospital of Qingdao University, China

^*Correspondance to: Hongzai Guan 

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Abstract

Objectives Epstein Barr Virus (EBV) infection is closely associated with occurrence of lymphoma; however, its pathogenesis remains unclear. The study investigates the relationship between EBV infection and chromosomal abnormalities in lymphoma and immunophenotyping. We also evaluated the effect of EBV on the prognosis of lymphoma. Methods Fluorescence quantitative polymerase chain reaction was used to detect the copy numbers of EBV-DNA from bone marrow in 14 cases of Hodgkin Lymphoma (HL), 136 cases of patients with Non-Hodgkin Lymphoma (NHL), and 37 cases of hematologically healthy control subjects. Results EBVDNA copies were found in 49 of 150 (32.7%) patients with lymphoma and 2 of 37 healthy control subjects (P0.05). In addition, EBV+ - lymphoma exhibited higher relapse and mortality rates, compared with EBV-lymphoma. Conclusion we conclude that EBV infection is correlated with the incidence of lymphoma and the infection rate of EBV shows no statistical significance in B-lymphoma and T-lymphoma. No statistical correlation between EBV infection and chromosomal abnormalities is indicated. EBV positive patients showed an unfavorable prognosis. Keywords: Malignant lymphoma; Chromosome; Epstein Barr virus; FQ-PCR; Immunophenotyping

Citation:

Zhang C, Guo X, Yang J, Guan H. Role of Epstein Barr Virus in the Attack of Mal ignant Lymphoma. J Hematol Mult Myeloma. 2018;3(1):1015.