J Hematol Mult Myeloma | Volume 7, Issue 1 | Case Report | Open Access
Ruobing Xiao*, Lucia Wolgast and Yanhua Wang
Department of Pathology, Montefiore Medical Center, New York, USA
*Correspondance to: Ruobing Xiao
Fulltext PDFMultiple myeloma is a hematologic malignancy primarily affecting plasma cells within the bone marrow and extramedullary tissues. Although extramedullary spread can occur, intrathecal involvement of the Central Nervous System (CNS) is exceedingly rare and poses serious diagnostic and therapeutic challenges. We present a case study of multiple myeloma with central nervous system involvement and peritoneal spread. The patient is a 64-year-old male with a history of multiple myeloma with IgG kappa light chain restriction diagnosed in 2010, status post autologous stem cell transplant over ten years ago, and peritoneal metastasis three years ago. The patient recently presented to the emergency department with lower limb pain, progressive weakness, and confusion. Lumbar puncture was performed, and cerebrospinal fluid was sent for cytology. Microscopic examination of the cerebrospinal fluid showed malignant plasma cells. The patient was subsequently treated with biweekly intrathecal chemotherapy.
Myeloma; Peritoneal Metastasis; Cytology; Bone Marrow
Xiao R, Wolgast L, Wang Y. Multiple Myeloma with Central Nervous System Involvement and Peritoneal Metastasis: A Case Report. J Hematol Mult Myeloma. 2025; 7(1): 1031..