J Gynecol Oncol | Volume 7, Issue 1 | Case Report | Open Access
Clark KA*, Schumann T, Brunnabend M, Karesh E, Unterman K and Dorr A
Alabama College of Osteopathic Medicine, Dothan, USA
Department of Obstetrics and Gynecology, Winnie Palmer Hospital, Orlando, USA
Department of Obstetrics and Gynecology, Mercy Hospital, Oklahoma City, USA
Alabama College of Osteopathic Medicine, Dothan, USA
*Correspondance to: Kathleen Clark
Fulltext PDFUterine Carcinosarcoma (UCS) is a rare, highly aggressive, biphasic neoplasm of endometrial epithelial and heterologous mesenchymal components. The heterologous sarcomatous element describes the cancerous transformation of the mesenchymal cells into those not native to the uterus such as skeletal muscle, bone, or cartilage. These specific cancers exhibit Epithelial to Mesenchymal Transition (EMT), attributing to its aggressive metaplastic transformative abilities leading to a high recurrence rate and poor overall prognosis, often leading to extrauterine spread at the time of diagnosis. We present the case of a 70-year-old postmenopausal female with a chief complaint of heavy, daily vaginal bleeding characterized by uterine cramping, and abdominal pain as well as visualization of a large protruding cervical mass on examination. Endometrial biopsy revealed carcinosarcoma with heterologous rhabdomyosarcomatous differentiation. After referral to gynecological oncology, the patient underwent a total hysterectomy, bilateral salpingooophorectomy and sentinel lymph node mapping and biopsy with complete surgical resection leading to remission and clinical improvement. UCS management is complicated by its rarity and aggressive nature and has limited specific treatment guidelines. However, current guidelines consist of a multimodal approach, with comprehensive surgical staging, adjuvant chemotherapy agents and radiotherapy in select patients. This case underscores the clinical importance of early screening and diagnosis as well as continued efforts in molecular profiling as well as refining individualized multimodal treatment modalities.
Endometrial Carcinosarcoma; Hysterectomy; Diagnosis; Computed Tomography
Clark KA, Schumann T, Brunnabend M, Karesh E, Unterman K, Dorr A. Case Report: Endometrial Carcinosarcoma with Heterologous (Rhabdomyosarcomatous) Differentiation Presenting as Post- Menopausal Bleeding. J Gynecol Oncol. 2026; 7(1): 1085..