J Gynecol Oncol | Volume 6, Issue 1 | Case Report | Open Access

A Case Report of Synchronous Metastatic Neuroendocrine Tumor and Papillary Thyroid Cancer in the Setting of Lynch Syndrome

Rebecca Shin^1*, Sara Berlin², Melissa Hodeib³ and Alireza Abidi³

¹Adventist Health White Memorial Medical Center, USA ²Riverside Medical School, University of California, USA ³Kaiser Permanente Riverside Medical Center, USA

^*Correspondance to: Rebecca Shin 

Abstract

Introduction: This case report presents a patient with Lynch syndrome with primary neuroendocrine lung cancer and synchronous papillary thyroid cancer with focal metastasis of neuroendocrine cells of the thyroid. One year after diagnosis, this patient then had an incidental finding of focal ovarian neuroendocrine cells after risk-reducing bilateral oophorectomy for Lynch syndrome. Method: 52-year-old female who was found to have metabolically active lesions of the left lower lung and right thyroid lobe. The biopsies of the thyroid and left lung were remarkable for papillary thyroid carcinoma and grade 1 well-differentiated neuroendocrine tumor, respectively. Patient underwent complete left pneumonectomy and subsequent total thyroidectomy; a focal metastasis of neuroendocrine cancer was found on the thyroid pathology. Genetic testing was positive for Lynch syndrome. After one year of surgical and medical treatments, patient underwent risk-reducing laparoscopic bilateral oophorectomy for Lynch syndrome. Pathology was remarkable for two foci of neuroendocrine tumor on one of the ovaries. Discussion: To our knowledge, this is a rare case presentation that has not been reported in the literature and it proposes several suggestions. In the setting of metastatic neuroendocrine lung cancer to the thyroid and ovary and synchronous papillary thyroid cancer, a post-menopausal patient may benefit from an empiric oophorectomy. It also suggests the need for further investigation on the differentiating characteristics between primary and metastatic neuroendocrine ovarian cancer. Lastly, it also suggests a need for further exploration on Lynch syndrome and its role in neuroendocrine and thyroid cancer development.

Keywords:

Lynch syndrome; Thyroidectomy; Lung cancer; Hypothyroidism

Citation:

Shin R, Berlin S, Hodeib M, Abidi A. A Case Report of Synchronous Metastatic Neuroendocrine Tumor and Papillary Thyroid Cancer in the Setting of Lynch Syndrome. J Gynecol Oncol. 2024; 6(1): 1083..