J Dent Oral Biol | Volume 9, Issue 1 | Research Article | Open Access

Immunohistochemical Markers in Head and Neck Rhabdomyosarcoma of Pediatric Population – A Systematic Review

Sai Sudha M1, Subhashini P1, Senthil Kumar A2, Karthik S3*, Barun Kumar4 and Karthi Kumar M5

1Department of Pathology, Sree Balaji Medical College and Hospital, Chennai, India
2Department of Oral & Maxillofacial Surgery, Tamilnadu Govt Dental College Hospital, India
3Department of Dentistry/Oral and Maxillofacial Pathology, PSP Medical College Hospital and Research Institute,
4Oral and Maxillofacial Surgery, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, India
5University of Science and Technology in Fujairah, UAE

*Correspondance to: Karthik Shunmugavelu 

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Background: Mesenchymal cell origin tumor with malignant nature, rhabdomyosarcoma, a sarcoma of solid tumor type in pediatric population, presents different varied muscle cells architecture in the oral and maxillofacial region. Immunohistochemistry plays a pivotal role in the differentiation of rhabdomyosarcoma from other soft tissue tumors of pediatric population. Material and Methods: Major databases such as Medline were explored detailed literature search in resulting in a systematic review pertaining to immunohistochemistry of rhabdomyosarcoma especially in the oral and maxillofacial region of pediatric population, leading to determination of anatomy, classification, histopathology, age, gender and immunohistochemical markers. Results: Seven original research scientific articles pertaining to the head and neck pediatric rhabdomyosarcoma were highlighted depicting heterogenous cellular features, which is to be confirmed by immunohistochemistry. Conclusion: Histopathology plays an important role in the diagnosis of pediatric head and neck rhabdomyosarcoma whereas immunohistochemistry is the main differentiation factor in case of subtypes, nature, management and prognosis.


Pediatric; Rhabdomyosarcoma; Head; Neck; Oral; Maxillofacial; Pathology; Immunohistochemistry


Sai Sudha M, Subhashini P, Senthil Kumar A, Karthik S, Barun Kumar, Karthi Kumar M. Immunohistochemical Markers in Head and Neck Rhabdomyosarcoma of Pediatric Population – A Systematic Review. J Dent Oral Biol. 2024; 9(1): 1224. ISSN: 2475-5680.

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