J Dent Oral Biol | Volume 7, Issue 4 | Case Report | Open Access

Management of a Large Periapical Lesion by Endodontic Surgery Using Platelet Rich Fibrin

Nishant Sinha1, Ashish Kamboj1*, SS Chopra2, Ashok Rathod3, Debapreeti Mohanty4 and Prateek Mathur5

1Government Dental Centre, Leh, India
2Department of Dental Surgery, AFMC, Pune, India
3AFDC, New Delhi, India
4Department of Conservative Dentistry & Endodontics, KIDS, KIIIT-DU, Bhubaneswar, India
5Army Dental Corps, India

*Correspondance to: Ashish Kamboj 

Fulltext PDF


Periapical lesion develops after the necrosis of the pulp tissue or extensive periodontal disease. The ideal desirable outcome of the nature of wound healing after endodontic surgery should be regeneration and not repair. The outcome depends on the nature of the wound, the availability of progenitor cells, signaling molecules and micro-environmental cues such as adhesion molecules, extracellular matrix and associated non-collagenous protein molecules. The purpose of this case report is to add knowledge to the existing literature about the use of Platelet Rich Fibrin (PRF) in the treatment of a large periapical lesion. A periapical endodontic surgery was performed on a 22 years old female patient with a swelling in the upper front teeth region and large periapical radiolucency. The surgical defect was filled with PRF and also a PRF membrane was applied as a barrier membrane over the defect before suturing. Clinical examination revealed uneventful wound healing. Radiologically the defect has been reduced and bony trabeculations are visible after three months. On the basis of the result obtained in our case, we hypothesize that the use of PRF in the body cavity as well as application of PRF membrane might have induced the rapid rate of bone formation.


Periapical lesion; Platelet rich fibrin; Platelet rich fibrin membrane; Regeneration


Sinha N, Kamboj A, Chopra SS, Rathod A, Mohanty D, Mathur P. Management of a Large Periapical Lesion by Endodontic Surgery Using Platelet Rich Fibrin. J Dent Oral Biol. 2022; 7(4): 1200..

Subscribe to Our Newsletter