J Dent Oral Biol | Volume 5, Issue 2 | Research Article | Open Access

Distribution Pattern and Outcome of Primary Oral Mucosal Melanoma: A Systematic Review

Ilker Burgaz1, Ma Xiao-kun2 and Wang Dian-can2

1Department of Oral and Maxillofacial Surgery, Dental, Oral and Health Clinic, Istanbul, Turkey
2Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing,
People’s Republic of China

*Correspondance to: Wang Dian-Can 

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Background: Primary Oral Mucosal Melanoma (POMM) is an extremely rare malignant tumor with a very poor prognosis. Interestingly, various reports have shown its uneven distribution in the oral cavity and a predominance of POMM in areas of high mechanical stress like maxillary gingiva and hard palate. Objectives: This systematic review is focused on distribution, clinical significance and the outcome of POMM in the masticatory, lining and specialized mucosa. Data sources: With the search limited between 01-01-1998 to 11-26-2018, a systematic review of English electronic databases was done with ''oral'', "mouth'', "mucosal", "melanoma'' and a combination of these terms. By searching for references and/or bibliographies, a list of selected reviews and studies was prepared. Further, by consulting experts in the field, few more additional studies were identified. All the studies were restricted to humans. Only the studies written in the English language were included. Data extraction: A data collection table was used to retrieve information regarding patient characteristics, interventions, outcomes, and study design independently by two researchers. Study quality indicators were determined and papers were stratified accordingly. The collected data were analyzed. Data synthesis: A total of 27 articles met our inclusion criteria. The masticatory mucosa was the most common (87%) site of occurrence of POMM, followed by lining mucosa (11%) and specialized mucosa (2%). The prevalence of POMM was highest on the hard palate followed by gingiva with the ventral tongue being the rarest location. Limitations: This is a review of uncontrolled studies in which cases with any stage were included, treated with different operators and follow up duration was not uniform. The outcome information was not sufficient to have a conclusion about the prognosis of this disease in each type of mucosa. Conclusion: We suggest further studies with clear localization and outcome information about each type of mucosa to have a better understanding.


Oral; Mucosal; Melanoma; Malignant neoplasm


Burgaz I, Xiao-kun M, Dian-can W. Distribution Pattern and Outcome of Primary Oral Mucosal Melanoma: A Systematic Review. J Dent Oral Biol. 2020; 5(2): 1162. ISSN: 2475-5680.

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