J Clin Obstet Gynecol Infertil | Volume 4, Issue 1 | Research Article | Open Access
Gunjan Rai*, Sudhir Mansingh and Bikram Bhardwaj
Department of Obstetrics and Gynecology, Command Hospital, India
*Correspondance to: Gunjan Rai
Fulltext PDFAlloimmunization, often called Rh-isoimmunization, was first described in Rh negative women with an Rh-positive fetus, but it can occur with many other blood type incompatibilities. It is a condition that may occur during pregnancy when there is an incompatibility between mother’s blood type and fetus blood type. During pregnancy, red blood cells from fetus can cross placental barrier and there is formation of antibodies. Those antibodies can cross back through the placenta and destroy fetal RBCs causing fetal anemia and fetal hydrops. This is called hemolytic disease of the fetus. Still the fetal anemia due to red cell alloimmunization in Rh isoimmunized pregnancy is the leading cause of intra-uterine blood transfusion. However intra-uterine transfusion can be considered in severe fetal anemia of any other cause like Parvo B 19 viral infection. Access of umbilical vein also helps in transfusion of platelets in alloimmune thrombocytopenia and injection of drugs to fetus like anti-arrhythmic drugs in fetal arrhythmia. Ultrasound guided access of umbilical vein is common for all type of intra-uterine transfusion. We managed Rh isoimmunized pregnancies at our centre by intrauterine transfusions and even conservatively.
Rh isoimmunization; Intrauterine transfusion; Phototherapy; Exchange transfusion
Rai G, Mansingh S, Bhardwaj B. Successful Management of Rh Isoimmunized Pregnancies at a Tertiary Care Centre-Our Experience. J Clin Obstet Gynecol Infertil. 2020; 4(1): 1047..