Masachi Hanaoka1, Michi Hisano1, Keiko Tsukamoto1, Reiko Ito2, Yushi Ito1, Haruhiko Sago1, Akira Matsui2 and Koushi Yamaguchi1*
1Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan
2Depertment of General Medicine, National Center for Child Health and Development, Tokyo, Japan
Acute hepatitis by hepatitis B virus (HBV) genotype A causes long duration of hepatitis, and the carrier rate after acute infection is approximately 10%. The genotype A hepatitis has become the most common acute infection linked to horizontal transmission among young people in recent years. Increases in HBV genotype A-carrier mothers are expected in the near future in Japan, and prophylaxis against mother-to-child transmission for hepatitis B virus genotype A-carrier mothers will therefore be important in suppressing expansion of this viral infection. This report describes that infants born to HBV genotype A-carrier mothers have begun to appear in Japan and prevention of mother-to-child transmission (MTCT) was performed by administration of immunoglobulin derived from genotype A virus antigen with subsequent inoculation of vaccine derived from genotype C virus antigen.
Hepatitis B virus genotype A; Mother-to-child transmission; HBV immunoglobulin; HBV vaccine
Hanaoka M, Hisano M, Tsukamoto K, Ito R, Ito Y, Sago H, et al. Infants Born to HBV Genotype A-Carrier Mothers have Begun to Appear in Japan. J Clin Obstet Gynecol Infertil. 2017; 1(4): 1021.