J Clin Obstet Gynecol Infertil | Volume 8, Issue 1 | Research Article | Open Access
Gebremichael A, Hussien H, Alemu B, Kebede K and Siferih M*
1Department of Obstetrics and Gynecology, St. Paul’s Hospital Millennium Medical College, Ethiopia 2Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, St. Paul’s Hospital Millennium Medical College, Ethiopia 3Department of Public Health, St. Paul’s Hospital Millennium Medical College, Ethiopia 4Departmentof Obstetrics and Gynecology, Daruxannal Hospital, Burauo, Somaliland 5Department of Obstetrics and Gynecology, School of Medicine, Debremarkos University, Ethiopia
*Correspondance to: Melkamu Siferih
Fulltext PDFBackground: Preeclampsia is typically prevented by using low-dose aspirin in women with highrisk factors. Data on pregnant women who use low-dose aspirin to avoid preeclampsia are scarce in Ethiopia. This study aims to determine the prevalence and predictors of preeclampsia in women taking low-dose aspirin at a tertiary care hospital. Methods: An observational study was conducted retrospectively on pregnant women who were at high risk for preeclampsia and who were given low-dose aspirin for the prevention of preeclampsia at Saint Paul’s Hospital and Millennium Medical College, Addis Ababa, Ethiopia, from June 1st, 2018 to May 31st, 2022. Kobo Toolbox was used to extract the data and SPSS version 26 was utilized for data analysis. The preeclampsia syndrome predictors were found using a binary logistic regression model. Variables that had a p-value of 0.05 or lower were taken into consideration. Result: Data were extracted from the cards of 392 participants with a mean age of 29.7 years (SD ± 5.33) and included in the final analysis. The prevalence of preeclampsia syndrome was 19.4% (95% CI; 15-24%). Variables like: Older maternal age (≥ 35) (AOR=3.25, 95% CI (1.18-8.97)), nulliparity (AOR=11.59, 95% CI (2.81-27.70)), history of preeclampsia (AOR=4.11, 95% CI (1.289- 8.74), late initiation of low-dose aspirin (AOR=2.2 95% CI (1.60–4.21)), pregestational diabetes (AOR=2.88, 95% CI (1.07-77)), chronic hypertension (AOR=13.2, 95% CI (5.11-17.2)), two or more preexisting medical conditions (AOR=15.1; 95% CI (6.32-22.28)) were significantly associated with preeclampsia syndrome. Conclusion: Despite taking aspirin as a preventive strategy, preeclampsia struck a significant proportion of pregnant women. Older women, nulliparity, history of preeclampsia, chronic hypertension, late initiation of low-dose aspirin, pregestational diabetes, and two or more concomitant medical disorders were found to be predictors. Principally, nulliparity, chronic hypertension, and two or more medical disorders considerably amplify the risk. Priority should be given to pre-conceptional optimization of pre-existing medical conditions, early and routine prenatal care monitoring, and appropriate counseling of modifiable risk factors. Future researchers ought to concentrate on doing multicenter, larger cohort, more robust, more compliance-oriented studies.
Predictors; Preeclampsia; High-risk pregnant women; Low-dose aspirin; Ethiopia
Gebremichael A, Hussien H, Alemu B, Kebede K, Siferih M. Predictors of Preeclampsia in High-Risk Pregnant Women Prescribed Low-Dose Aspirin in a Resource-Limited Setting. J Clin Obstet Gynecol Infertil. 2024; 8(1): 1066..