J Cancer Clin | Volume 2, Issue 1 | Research Article | Open Access
Eilu E1,2*, Okiria JC2, Kato CD1,3, Akinola SA1, Rugamba A4, Kantarama E4, Daba TM4, Uwineza A4 and Adebayo IA1,4
1Department of Microbiology and Immunology, Kampala International University, Uganda
2Institute of Allied Health Sciences, Clarke International University, Uganda
3School of Biosecurity, Biotechnical and Laboratory Science, College of Veterinary Medicine, Animal Resources
and Biosecurity (COVAB), Makerere University, Uganda
4Department of Medical Biochemistry, Molecular Biology, and Genetics, School of Medicine and Pharmacy, College
of Medicine and Health Sciences, University of Rwanda, Rwanda
*Correspondance to: Eilu Emmanuel
Fulltext PDFDifferent studies show that high-risk HPV genotypes are the main etiological agents for cervical
cancer development and cancer-related deaths in women worldwide. In Uganda, cervical
malignancies due to Human Papillomavirus (HPV) are predominant among sexually active women.
However, data on the incidence and clinical spectrum of lesions associated with high-risk HPV
infection is inadequate. The current study was aimed to determine incidence and clinical spectrum
of lesions induced by high-risk oncogenic HPV types among study participants in Eastern Uganda.
We piloted a prospective follow-up study among 1,077 women aged 15 to 55 years to assess the
incidence and clinical spectrum of lesions associated with Human Papillomavirus infections (HPV).
HPV Real-Time PCR using HPV High-Risk Screen Real-TM Quant 2x kit (Sacace, Biotechnologies,
Italy) was used for genotyping high-risk HPV types. Four hundred and sixteen (416) of 1,077
(38.6%) women were monitored for an average time of 18 months (inter-quartile range 9.6-
26.6). Forty-three (43) women had incident HPV infections during 214 person-years of follow-up
reflecting an incidence rate of 20.1 per 100 person-years. Incident HPV infections were marginally
associated with HIV positivity (RR=3.0, 95% CI: 0.8-8.2) and usage of oral contraceptives (RR=2.6,
95% CI: 1.4-2.8) but not with the age of study subjects, or number sexual partners. Clearance for
high-risk HPV infections was frequently ranging between 37.5% and 100.0% for high-risk types.
Only 41.3% of women cleared all their infections. Clearance was associated with HIV negativity
(Adjusted clearance =0.3, 95% CI: 0.2-0.8) but not with age at study entry or oral contraceptive
usage. Incident HPV infections and clearance of HPV type-specific infections were common among
study participants. We also found a high prevalence of high-risk HPV types in cervical lesions,
which reveal an association between cervical lesions and high-risk HPV types.
Human papillomavirus; Cancer of the cervix; Incidence rate
Eilu E, Okiria JC, Kato CD, Akinola SA, Rugamba A, Kantarama E, et al. Type- Specific HPV Incidence and Clinical Spectrum of Lesions Induced by High- Risk Oncogenic HPV Types among Study Participants in Eastern Uganda. J Cancer Clin. 2023; 2(1): 1010..