J Cancer Clin | Volume 1, Issue 1 | Research Article | Open Access

Role of P53 and Ki-67 as Prognostic Factors in Ovarian Cancer: Systematic Review and Pooled-Analysis

Nicoletta Staropoli1, Domenico Ciliberto1, Eleonora Iuliano1, Antonina Maria De Angelis1, Angela Salvino1, Pierfrancesco Tassone2, Maria Teresa Di Martino2* and Pierosandro Tagliaferri1*

1Department of Medical Oncology, Magna Graecia University, Italy
2Department of Translational Medical Oncology Units, Magna Graecia University, Italy

*Correspondance to: Pierosandro Tagliaferri 

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Introduction: Ovarian Cancer (OC) is the most lethal cancer among gynecological malignancies. In the last years, several studies clarified that OC is characterized by different clinical entities that share only the anatomic site. The aim of this review is the evaluation of Ki-67 and p53 as prognostic factors in OC.
Methods: By searching Pubmed and abstracts from major cancer meetings, we selected clinical trials within the timeframe 2000-2016. We evaluated all data retrievable and we performed a pooledanalysis by random effect model. The endpoints were the Overall Survival (OS) in terms of Hazard Ratios (HRs) of survival outcomes.
Results: We observed a more severe outcome for patients over-expressing Ki-67. However, the overall data of our PFS meta-analysis did not reach the statistical significance (HR 1.98 CI 0.60-6.52, p=0.26). The indirect comparison of p53 studies, here reported, highlighted a possible correlation between patients OS and p53 status. Conclusions: We hypothesize that both Ki-67 and p53 alterations retain a prognostic role in terms of OS in OC.


Staropoli N, Ciliberto D, Iuliano E, De Angelis AM, Salvino A, Tassone P, et al. Role of P53 and Ki-67 as Prognostic Factors in Ovarian Cancer: Systematic Review and Pooled-Analysis. J Cancer Clin. 2018; 1(1): 1002.

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