Int J Thyroid Res | Volume 1, Issue 1 | Research Article | Open Access
George Zhu
Department of Oncology, Tehran University of Medical Science, Iran
*Correspondance to: George Zhu
Fulltext PDFObjective: Traditional systems of medicine all over the world even traditional medicine and cancer have been using plants and plants products for therapeutic intention. The purpose of this retrospective trial is to assess the clinical efficacy of chemotherapy in conjunction with TCM for a broad variety of cancers.
Methods: 75 patients with available cancers were concluded in the study during September 1993 - May 2018. The sex ratio of male: female was 50:25 respectively. The mean age at onset was 46.9 years (range 10-79 years). All patients were treated with different dosage of various chemotherapy in combination with TCM or traditional medicine alone. The detail prescription of TCM varied among a broad variety of carcinomas (see full text case reports). The criteria of Complete Remission (CR) and/or Partial Remission (PR) is according to the rules where physicians have in common with in clinics.
Results: In 75 cases, the CR was obtained in 33(44%) advanced cancers, a short CR in 11(14.7%) cases, PR in 25(33.3%) cancers, Stable disease in 6 cases. As to approach to the schedule of drug administration, 16 lymphoma obtained CR via COMA (CTX, VCR, MMC, and ADM) regimen and TCM or antibiotics and immunotherapy. Five advanced gastric cancer were successfully treated using MFC and cinobufacini/cantharidin, and TCM. In follow up, one HCC accompanied with colon polyps obtained CR via hepatectomy and targeting oncogenic receptor tyrosine kinase inhibitor sorafenib. Among two lung cancers, one female with metastatic lung cancer was given targeting oncogenic receptor EGFR gefitinib therapy after the combination chemotherapy, which was stable disease for 8+ months. CR can also be achieved in one advanced cholangi carcinoma and one advanced gallbladder cancer through major protocol of TCM and the addition of small dosage of chemotherapy. Thyroid cancer was placed on the primary use of TCM. The crude herbs consisted of sargassum, tangle, Oyster (mussels), Poria cocos, Ophiopogon japonicus, Prunella vulgaris, Taraxacum, Scrophularia ningpoensis, Cremastra appendiculata, Trichosanthes Kirilowii, Sophora subprostrata, Houttuynia cordata, Scutellaria barbata d. don and Oldenlandia diffusa roxb. Among those long-term survivors, 31 carcinomas obtained in disease-free survival over 5 years, 20 cancers were survival over 10 years, the longest four patients over 25 years.
Conclusion: In this study, I experienced that a CR was a pivotal influencing factor in those longest survival patients and traditional medicine was also recommended. Downregulating oncogenic receptors may be useful paradigm and perspective in currently the third line setting of clinical target therapy and in rendering our better understanding of cancer biology.
Cancer chemotherapy; Traditional medicine; Target therapy
Zhu G. How I Treat Patients with Advanced Cancer Following Chemotherapy and Traditional Medicine (75 Cases). Int Thyroid Res. 2018; 1(1): 1001.