Ann Transplant Res | Volume 4, Issue 1 | Research Article | Open Access
Harsányi M1, Rárosi F2, Keresztes C3, Németh T1, Manafzadeh AR1, Nagy-Turkevi S4 and Borda B1*
1Department of Surgery, Albert Szent-Györgyi Medical School, University of Szeged, Hungary 2Department of Medical Physics and Informatics, Albert Szent-Györgyi Medical School, University of Szeged, Hungary 3Department for Medical Communication and Translation Studies, Albert Szent-Györgyi Medical School, University of Szeged, Hungary 4Institute of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Hungary
*Correspondance to: Bernadett Borda
Fulltext PDFIntroduction: Cardiovascular diseases are the leading causes of death after kidney transplantation, one of the major risk factors of which is Post Transplant Hypertension (PTHT), which is often unrecognized and therefore untreated. Material and Methods: In this study, the incidence and risk factors of PTHT were examined. The effect of blood pressure on graft function and that of renin and aldosterone levels on renal function were assessed. The effect of hypertension on renal histology one year after transplantation was evaluated. Results: The incidence of PTHT was 42%. Regarding the risk factors, no significant difference was revealed. PTHT was significantly higher in cyclosporine users (P=0.021) than in tacrolimus users. Significant differences were found in case of renal function: serum creatinine (P=0.024) urea (P=0.005) and eGFR (P=0.036) in patients with PTHT. The analysis of renin and aldosterone levels confirmed that renin levels significantly changed serum creatinine (P=0.019) and urea (P=0.027) values. The donor’s systolic blood pressure significantly affected the development of arteriolar hyalinosis (normal vs. arteriolar hyalinosis; N=13 vs. N=56; P=0.023). The incidence of interstitial fibrosis and tubular atrophy (P=0.0001) and acute cellular rejection (P=0.033) was significantly higher in patients with systolic blood pressure one year after the surgery. Discussion: The harmful effect of newly developed hypertension after transplantation on the graft was seen even one year after transplantation not only in renal function but in morphology as well. Conclusion: Therefore, we consider it essential to monitor blood pressure regularly and to start antihypertensive therapy if necessary.
Immunosuppressive drugs; Kidney function and morphology; Kidney transplantation; Post-transplant hypertension
Harsányi M, Rárosi F, Keresztes C, Németh T, Manafzadeh AR, Nagy- Turkevi S, et al. Risk Factors of Post-Transplant Hypertension and Its Effects on Renal Allograft Function and Histopathology. Ann Transplant Res. 2024; 4(1): 1019..