Sahr Yambasu, Sami Abd Elwahab* and Ivan Ivanovski
Department of Surgery, Wexford General Hospital, Republic of IrelandFulltext PDF
Signet ring cell carcinoma of the colon is an uncommon, aggressive variant of colorectal cancer that is typically advanced at presentation. 5-year survival is poor, particularly when compared to adenocarcinoma of the colon. Despite being first reported on in 1951, the amount of clinical research that has been carried out on this entity is limited. Here we report the case of an 88-yearold male who presented with signet ring cell carcinoma of the colon and underwent surgical resection. Our literature review describes the many factors that contribute to the poor prognosis and high recurrence seen in signet ring cell carcinoma of the colon. There is evidence that survival is improved in cases that are recognized early and undergo R0 resection, but clinical guidelines to aid early diagnosis and efficient management are lacking. Evidence-based clinical guidelines on the optimal diagnosis and management of this condition are needed. However, the rarity of this cancer and its propensity for insidious onset and aggressive course prove a challenge to the development of such guidelines.
Yambasu S, Abd Elwahab S, Ivanovski I. Signet Ring Cell Carcinoma of the Colon: Exploring the Literature Surrounding this Uncommon Clinical Entity. Ann Surg Case Rep. 2018; 1(1): 1004.