Ann Stem Cells Regen Med | Volume 2, Issue 1 | Review Article | Open Access

Biomedical Applications of Induced Pluripotent Stem Cells

Neveen A Salem1,2*

1Department of Biochemistry, University of Jeddah, Saudi Arabia 2Department of Narcotics, Ergogenic Aids and Poisons, Division of Medical Research, National Research Centre, Egypt

*Correspondance to: Neveen A Salem 

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Induced Pluripotent Stem Cells (iPSCs) which are efficiently produced from somatic cells by the introduction of four transcription factors (Oct4, Sox2, Klf4, and c-Myc) in fibroblasts could circumvent the restrictions of multipotent stem cells that obligated to differentiate into only several lineage cells and also, the ethical argument about ESCs that causes oocytes and embryo destruction. In addition, iPSCs are powerful tools applicable in biomedicine, cell therapy, pharmacology and toxicology. Therefore, the use of iPSCs in stem cell therapy has immense prospects and offer remarkable applications in regenerative medicine. This review aimed to summarize the most recent findings on iPSCs and focus on their biomedical applications.


Salem NA. Biomedical Applications of Induced Pluripotent Stem Cells. Annals Stem Cell Regenerat Med. 2019; 2(1): 1013..

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