Ann Stem Cells Regen Med | Volume 1, Issue 1 | Review Article | Open Access

Autologous Graft Versus Host Disease: An Updated Review

Kanfar S and Al-Anazi KA*

Department of Hematology and Hematopoietic Stem Cell Transplantation, King Fahad Specialist Hospital, Saudi Arabia

*Correspondance to: Al-Anazi KA 

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Graft versus host disease is an increasingly recognized complication of autologous hematopoietic stem cell transplantation. It may occur spontaneously, but can be induced by a number of immunosuppressive agents. There are specific risk factors for the evolution of this complication. Clinically and histologically, it resembles graft versus host disease occurring after allografting. It varies in severity from mild and self limited illness to severe forms that may become life-threatening. Early recognition and prompt institution of immunosuppressive therapy are essential to prevent further complications.


Graft versus host disease; Hematopoietic stem cell transplantation; Draft versus tumor effect; Engraftment syndrome; Immunosuppressive therapy


Kanfar S, Al-Anazi KA. Autologous Graft Versus Host Disease: An Updated Review. Annals Stem Cell Regenerat Med. 2018;1(1):1002.

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