Ann Stem Cell Res Ther | Volume 5, Issue 1 | Case Report | Open Access

Mesenchymal Stem Cell Conditioned Media Induces Hair Regeneration in Alopecia Areata: A Case Study

Anjum Mahmood¹, Rajasekar Seetharaman¹, Prashant Kshatriya¹, Divyang Patel¹, Rangnath Mishra² and Anand S Srivastava^2*

¹Department of Stem Cell Therapy, Global Institute of Stem Cell Therapy and Research Pvt. Ltd, India ²Department of Stem Cell Therapy, Global Institute of Stem Cell Therapy and Research, USA

^*Correspondance to: Anand S Srivastava 

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Abstract

Alopecia Areata (AA), a hair loss condition caused primarily by autoimmune disorder, affects significant population globally. The disease hampers quality of life causing anxiety and low selfesteem in patients. This case reports discuss about condition of an alopecia areata patient and her subsequent treatment with Mesenchymal Stem Cell derived Conditioned Media (MSC-CM). The severity of disease was assessed by calculating Severity of Alopecia Tool (SALT) score which was 6%. The topical treatment for two months resulted in visible hair growth in vertex scalp area with SALT score approaching 0%. MSCs secrete number of growth factors, cytokines, lipid vesicles, and paracrine molecules in surrounding media which may regulate growth of hair follicles, vascularization, and morphogenesis. This report indicates that topical treatment of MSC-CM can alleviate alopecia condition and promote hair growth. This may be mediated through passive diffusion of paracrine factors and exosomes.

Keywords:

Mesenchymal stem cells; Conditioned media; Aopecia areata; Hair regeneration; Hair regrowth

Citation:

Mahmood A, Seetharaman R, Kshatriya P, Patel D, Mishra R, Srivastava AS. Mesenchymal Stem Cell Conditioned Media Induces Hair Regeneration in Alopecia Areata: A Case Study. Ann Stem Cell Res Ther. 2021;5(1):1041..