Ann Neurol Surg | Volume 6, Issue 1 | Research Article | Open Access
Yan X, Li Y, Tong Y, Chen X and Wang L*
Department of Pain Management, Jiujiang University Affiliated Hospital, China
*Correspondance to: Libin Wang
Fulltext PDFBackground: Asari Radix Et Rhizoma is extensively used to treat trigeminal neuralgia in China. However, the underlying mechanism of Asari Radix Et Rhizoma in the treatment of trigeminal neuralgia is unknown. Objective: Investigate the possible pharmacological mechanism of Asari Radix Et Rhizoma in the treatment of trigeminal neuralgia using network pharmacology and molecular docking. Methods: The TCMSP database was used to retrieve the active components of Asari Radix Et Rhizoma. The essential components of Asari Radix Et Rhizoma were obtained by drawing an active component-target network diagram with Cytoscape software. The corresponding targets were then obtained from the TCMSP database. The GeneCards, DisGeNET, and OMIM databases were searched for targets associated with trigeminal neuralgia. The String database was used to create a PPI network of common pharmaceutical and ailment targets before obtaining the core targets. The David database was used for common target GO enrichment and KEGG pathway analysis. After that, AutoDock performed molecular docking between the critical component and the critical target. Results: According to a review of the literature, the key components of Asari Radix Et Rhizoma in the treatment of trigeminal neuralgia are kaempferol, Cryptopin, and Sesamin, which may act on key targets like AKT1, JUN, ESR1, TNF, and MAPK8. KEGG enrichment analysis revealed the following key pathways: Lipid and atherosclerosis, Fluid shear stress and atherosclerosis, AGERAGE signaling route in diabetic complications, TNF signaling pathway, Estrogen signaling pathway, and so on. However further research is needed to establish the specific mechanism of Asari Radix Et Rhizoma. The affinity between the core components and core components was shown by molecular docking studies. Conclusion: The article provided a preliminary explanation of the possible mechanism of Asari Radix Et Rhizoma in the treatment of trigeminal neuralgia, which can serve as a theoretical foundation and evidence for further experimental research.
Asari Radix Et Rhizoma; Trigeminal neuralgia; Network pharmacology; Molecular docking
Yan X, Li Y, Tong Y, Chen X, Wang L. Exploring the Pharmacological Mechanism of Asari Radix Et Rhizoma against Trigeminal Neuralgia: A Network Pharmacology and Molecular Docking Approach. Ann Neurol Surg. 2024; 6(1): 1025.