Ann Med Med Res | Volume 8, Issue 1 | Research Article | Open Access

The Role of m6A Demethylase ALKBH5 in Decidualization

Sihui Hea^1,2, Weike Li^1,2, Rufei Gaob^2,3, Xuemei Chenb^2,3, Jing Long^1,2, Chenxi Chen^1,2, Dexian Dai^2,3 Yingxiong Wang^1,2 and Na Li^1,2*

¹School of Basic Medicine, Chongqing Medical University, China  ²Joint International Research Laboratory of Reproduction and Development, China  ³Department of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, China

^*Correspondance to: Na Li 

Abstract

Decidualization is a crucial process for pregnancy, yet its underlying mechanism remains unclear. ALKBH5 (α-ketoglutarate-dependent dioxygenase alkB homologue 5) is an m6A demethylation enzyme that catalyzes m6A demethylation. However, no studies have reported the function of ALKBH5 in decidualization. In this study, we explored the role of the ALKBH5 and the results showed that a significant upregulation of ALKBH5 expression accompanied by a decrease in the total m6A level during decidualization. Furtherly, Down-regulation of ALKBH5 resulted in increased the total m6A level, leading to inhibition of stromal cell proliferation, induction of cell apoptosis, and ultimately impairing decidualization. This study firstly reveals that ALKBH5 is essential for decidualization. The findings may address the research gap pertaining to the regulation of ALKBH5 during decidualization and offer novel insights into m6A modification in this process.

Keywords:

ALKBH5 apoptosis proliferation decidualization; Endometrium; Pregnancy diseases

Citation:

Hea S, Li W, Gaob R, Chenb X, Long J, Chen C. The Role of m6A Demethylase ALKBH5 in Decidualization. Ann Med Medical Res. 2025; 8: 1085..