Ann Infertil Reprod Endocrinol | Volume 2, Issue 1 | Case Report | Open Access

Leptin, Adiponectin, and Soluble Delta-Like 1 Homolog (sDlk1) Levels During Pregnancy in a Patient with Familial Partial Lipodystrophy

Mirka Ruch*, Christoph Schmid, Cornelia Zwimpfer and Oliver Tschopp

Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Zurich, Switzerland

*Correspondance to: Mirka Ruch 

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Abstract

Background: Lipodystrophy is characterized by decreased and dysfunctional adipose tissue, severe insulin resistance, and decreased fertility. Patients with lipodystrophy lack adipokines, including leptin and adiponectin. Case: A woman with familial partial lipodystrophy and poorly controlled diabetes mellitus became spontaneously pregnant. At baseline, serum leptin and adiponectin levels were low. During pregnancy, adiponectin tended to decrease further while there was a substantial increase in leptin and sDlk1; values returned to baseline after delivery. The pregnancy was uneventful, the blood sugar well controlled. A healthy girl was born. Conclusion: Blood sugar control was excellent during pregnancy. Apart from improved monitoring and intrinsic motivation, placental (leptin) and fetal (sDlk1) hormones may have had a beneficial impact on maternal metabolism.

Keywords:

Familial lipodystrophy; Pregnancy; Leptin; Adiponectin; sDlk1

Citation:

Ruch M, Schmid C, Zwimpfer C, Tschopp O. Leptin, Adiponectin, and Soluble Delta-Like 1 Homolog (sDlk1) Levels During Pregnancy in a Patient with Familial Partial Lipodystrophy. Ann Infert Rep Endocrin. 2019;2(1):1017..

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