Ann Diabetes Res | Volume 5, Issue 1 | Research Article | Open Access

Diabetes Mellitus with Uncontrolled Glycemia and its Impact on Mortality from the Novel Coronavirus: A Narrative Review

Silas Melo Ribeiro1, Dalvan Jose de Almeida Silva1, Alberto Barcelo1,2 and Arise Garcia de Siqueira Galil1*

1Medical School of Federal University of Juiz de Fora, Brazil 2Department of Public Health Science, University of Miami, USA

*Correspondance to: Arise Garcia de Siqueira Galil 

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Introduction: The novel coronavirus pandemic characterized by its growing potential for dissemination and the rapid spread of infection around the world. During the pandemic, control of chronic conditions such as Diabetes Mellitus (DM) has become more demanding. Objectives: To evaluate the most frequent conditions leading to uncontrolled glycemia in patients with diabetes infected with the novel coronavirus, verifying the association between disease severity and mortality. Methods: We conducted a narrative review of studies on the novel coronavirus that contained information on DM and its metabolic control. The Science Direct, Lilacs, Scielo, VHL Regional Portal, and PubMed databases were assessed as part of the bibliographical search strategy using the search terms "diabetes mellitus" and "glycemic index" or "glycemic load" or "blood glucose" and "novel coronavirus" or "COVID-19" and "mortality." Studies published from December 1st, 2019 to May 1st, 2020 (date of search) identified. We included studies in adult humans infected with the novel coronavirus in which there was an association of DM. The chosen languages were English and Spanish. We excluded animal studies, studies involving children and adolescents, abstracts of congresses or symposia, and book chapters. Results: For the proposed review, 74 articles identified in PubMed and 11 studies in Science Direct, but no articles with the descriptors found in Scielo, BSV, Lilacs, or VHL Regional Portal. After further screening, 17 articles were included for this review. Final Comments: Patients with diabetes infected with the novel coronavirus frequently also had a lack of glycemic control, which was associated with a greater severity of the infectious disease, greater number of hospitalizations, and higher mortality than was found in infected patients without diabetes. Glycemic control during the course of COVID-19 considered a goal. To explain the relationship between diabetes and COVID-19, several mechanisms proposed and reported.


Diabetes mellitus; Glycemic load; Novel coronavirus; COVID-19; Mortality


Ribeiro SM, de Almeida Silva DJ, Barcelo A, de Siqueira Galil AG. Diabetes Mellitus with Uncontrolled Glycemia and its Impact on Mortality from the Novel Coronavirus: A Narrative Review. Ann Diabetes Res. 2021;5(1):1014..

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