Shigeru Hirano1*, Mami Kaneko2 and Yo Kishimoto2
1Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Japan
2Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Japan
Introduction: Vocal fold atrophy and scar are featured with altered histological architecture of the vocal fold mucosa, which leads to permanent intractable dysphonia. Although there has been no optimal treatment for this entity, basic fibroblast growth factor (bFGF) has proven to be effective for the treatment of vocal fold scar and atrophy. Local injection of bFGF into the vocal fold proved positive effects in preliminary studies. Subsequent large series of patients’ data were reviewed and reported here. Study
Method: Sixty cases (35 atrophy and 25 scar) were treated by local injection of bFGF. Injection regimen was to locally apply 10 micrograms of bFGF in 0.5mL saline into each vocal fold under topical anesthesia repeatedly (4 times with interval of one week between each injection). Therapeutic outcomes were retrospectively reviewed during the follow up periods of 3 months through 12 months (mean period: 4.5 months).
Results: Maximum phonation time, voice handicap index (VHI)-10, and GRBAS scale were assessed and were significantly improved in both atrophy and scar cases. Success rate, defined by improvement of VHI-10 more than 5, was 89.6%, 72% in atrophy and scar patients, respectively.Temporal erythema was observed in 34 cases (52.5%), but no major adverse effects were observed.
Conclusion: Local injection of bFGF has shown to be effective for improvement of vocal function in vocal fold atrophy and scar.
Vocal fold atrophy; Scar; Basic fibroblast growth factor; Phonatory outcome
Hirano S, Kaneko M, Kishimoto Y. Regenerative Effects of Local Injection of Basic Fibroblast Growth Factor into the Vocal Fold Atrophy and Scarring: Results of 60 Cases. Ann Clin Otolaryngol. 2016;1(1):1005.