Trad Dorra*, Sabbah Meriam, Ben Aounallah Imen, Bellil Nawel, Elloumi Héla, Ouakaa Asma, Bibani Norsaf and Gargouri Dalila
Department of Gastroenterology, Habib Thameur Hospital, TunisiaFulltext PDF
Introduction: Chronic hepatitis B and C remain the leading causes of cirrhosis and Hepatocellular Carcinoma (HCC) in Africa and South East Asia. In Tunisia, they account for more than 75% of the etiologies of this cancer. The purpose of this study was to compare the clinical features and survival in patients with Hepatitis B Virus-related Hepatocellular Carcinoma (HBV-HCC) and Hepatitis C Virus-related Hepatocellular Carcinoma (HCV-HCC). Patients and Methods: A retrospective study (January 2002 to December 2017) including all cases of HCC developed on post viral B and C cirrhosis, diagnosed in Gastroenterology department of Habib Thameur Hospital was conducted. Epidemiological, clinical, biological, morphological characteristics, therapeutic modalities and evolution were compared between HBC and HCV related HCC. Results: A total of 84 cases of HCC were included: 53 patients with HCV-HCC and 31 patients with HBV-HCC. The mean age of HBV-HCC patients was 60.1 years, while it was 68.9 years in HCV-HCC patients (p=0.03). The male/female ratio was 9.3 in HBV-HCC, while it was 1.4 in HCV-HCC (p<0.001). The mean alpha-fetoprotein level in HBV-HCC was 16196 ng/ml, while it was 28148 ng/mL in HCV-HCC (p=NS). The mean tumor size was 50.1 mm in HBV-HCC, while it was 44.5 mm in HCV-HCC (p=NS). According to the BCLC classification, patients with HBV-HCC were classified in stage A in 6.4% of cases (N=2), in stage B in 22.5% of cases (N=7), in stage C in 38.7% of cases (N=12) and stage D in 32.2% of cases (N=10). Patients with HCV-HCC were classified in stage A in 26.4% of cases (N=14), in stage B in 30.1% of cases (N=16), in stage C in 20.7% of cases (N=11) and stage D in 22.6% of cases (N=12) (p=0.05). The mean survival was 8.6 months in HBV-HCC, while it was 23.9 months in HCV-HCC (p=0.03). Conclusion: Compared with HBV-HCC patients, HCV-HCC patients were older, had a lower male/female ratio, were diagnosed at a less advanced stage and had a better survival.
Hepatocellular carcinoma; Cirrhosis; Viral hepatitis; Prognosis
Dorra T, Meriam S, Aounallah Imen B, Nawel B, Héla E, Asma O, et al. Characteristics and Survival during Hepatocellular Carcinoma: Comparison between Hepatitis B and C Viruses. Ann Clin Hepatol. 2019; 3(2): 1015..