Ann Clin Anesth Res | Volume 7, Issue 1 | Research Article | Open Access
The Effect of Sedation on Renal Function in ICU Patients: A Systematic Review
Department of Anesthesiology and Intensive Care, Odense University Hospital, Denmark
*Correspondance to: Palle Toft
Fulltext PDFSedatives are administered to the majority of critically ill patients in the ICU. Sedatives are important to diminish agitated delirium and anxiety. The use of sedatives might however harm organ function. Kidney injury is one of the most common causes of mortality in the ICU. We present a systematic literature review aimed to summarize the existing evidence of the effect of sedatives on renal function. Dexmedetomidine appears to have no, or maybe a positive effect on renal function. Concerns regarding the increased plasma levels of inorganic fluoride during sevoflurane sedation and its negative effect on renal function seem to be of irrelevancy. A higher incidence of renal impairment is observed following midazolam sedation compared to propofol. Further studies are required to decide if non-sedation is associated with a better renal function.
Critically ill; Renal function; Non-sedation; sedation
Abildgren L, Logadóttir G, Úlfhéðinsdóttir RL, Toft P. The Effect of Sedation on Renal Function in ICU Patients: A Systematic Review. Ann Clin Anesth Res. 2023; 7(1): 1048..