Ann Chron Dise | Volume 2, Issue 1 | Research Article | Open Access

25-Oh Vitamin D3/D2 Levels in Osteoarthritis and Rheumatoid Arthritis Patients

Tsvetelina Velikova1*, Russka Shumnalieva2, Kalina Tumangelova-Yuzeir3, Darina Kachakova4, Ekaterina Ivanova-Todorova3, Dobroslav Kyurkchiev3 and Simeon Monov2

1Department of Clinical Immunology, University Hospital Lozenetz, Bulgaria
2Department of Clinic of Rheumatology and Internal Medicine, Medical University-Sofia, Bulgaria
3Department of Clinical Immunology, St. Ivan Rilski Hospital,Medical University-Sofia, Bulgaria
4Department of Medical Chemistry and Biochemistry, Medical University-Sofia, Bulgaria

*Correspondance to: Tsvetelina Velikova 

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Abstract

Background and
Objectives: Vitamin D exerts many other extraskeletal effects than the pivotal role in mineral metabolism, thus, deficiency of vitamin D has been shown not only in degenerative bone disease but also in many autoimmune diseases. We aimed to investigate the serum levels of 25-OH Vitamin D3/D2 in a Bulgarian cohort of patients with Osteoarthritis (OA) and Rheumatoid Arthritis (RA) and to establish correlations with some demographic and clinical, laboratory and instrumental findings.
Materials and Methods: 25-OH vitamin D3/D2 levels were assessed in serum samples of thirtyfive patients as follows: fifteen OA patients, twenty with RA, and 16 healthy controls, by automated ELISA.
Results: We found that the levels of 25-OH Vit.D3/D2 in OA patients (13.51 ± 7.89 ng/ml) differed significantly (p=0.002) from the RA patients (21.27 ± 6.77 ng/ml) and healthy controls (22.86 ± 7.91 ng/ml). The mean levels of 25-OH Vit.D3/D2 in OA patients were interpreted as insufficient, close to the defined deficiency (<12 ng/ml), whereas the mean levels in RA patients and healthy controls were evaluated as sufficient. Lower average levels of 25-OH Vit.D3/D2 were documented in women than in men in both OA and RA patients, and the lowest mean level of 25-OH vitamin D3/D2 in OA patients was observed among patients between 41-60 years (p=0.002). RA patients on disease modifying anti-rheumatic drugs exerted higher levels of 25-OH Vit.D3/D2 compared to the patients without therapy (p=0.068).
Conclusion: We could suggest that vitamin D supplementation in OA patients would be of benefit for them.

Keywords:

25-OH vitamin D; Vitamin D2; Vitamin D3; Osteoarthritis; Rheumatoid arthritis

Citation:

Velikova T, Shumnalieva R, D, Ivanova-Todorova E, Kyurkchiev D, et al. 25-Oh Vitamin D3/D2 Levels in Osteoarthritis and Rheumatoid Arthritis Patients. Ann Chron Dise. 2018; 2(1): 1004.

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