Andreas C Petropoulos1-3, Alexandros Lagos1, Natalia Tourkantoni1 and Maria Moschovi1*
1Department of Pediatrics, Division of Hematology-Oncology Unit, National and Kapodistrian University of Athens, Greece
2Department of Pediatrics, The “Aziz Aliyev” National Postgraduate and CME Medical Training Center, Greece
3Department of Pediatrics, Merkezi Klinika, Baku, Azerbaijan, Greece
Introduction: Mixed cellularity Hodgkin’s Lymphoma (HL) is a subtype of classic HL (c-LH), constituting the second most common subtype and 15% to 30% of all cases of HL. It is mostly observed in patients with either Epstein-Barr Virus (EBV) or Human Immunodeficiency Virus (HIV) infection, having less inheritance rate comparing to other subtypes. Familial HL is very rare.
Aim: The aim of this paper is to present a case of familial HL and to review the literature about the incidence and the relationship by histology, age at diagnosis, and gender.
Materials and Methods: Two siblings, a girl 15-year old and a boy 25-year old, presented with HL, stage IIIs, with the same affected sites of lymph nodes. The open node biopsy revealed the histological type of mixed cellularity c-HL, in both cases. At the biopsy specimen, both cases were negative for EBV.
Results: The girl achieved remission with chemotherapy, only. The boy received also initially chemotherapy but due to relapse during chemotherapy, radiotherapy was added. Unfortunately, he succumbed from refractory disease. The girl, up to date remains in first remission, 10 years after the diagnosis. By contrast, her older brother had a poor outcome.
Conclusion: It is a report of familial HL in two siblings. The only apparent difference between the two cases was the presenting age and gender. The girl was diagnosed at the age of 15 years old and the boy at the age of 25 years old. Considering that both patients where similar on their disease characteristics and both where negative for EBV infection, it seems that the age of onset and maybe the gender in this subtype of HL, has a crucial role on the outcome in familial cases of the disease.
Familial hodgkin’s lymphoma; Mixed cellularity classical hodgkin lymphoma; Familial hodgkin’s lymphoma-EBV negative
Petropoulos AC, Lagos A, Tourkantoni N, Moschovi M. Familial Hodgkin Lymphoma: A Case Report and Sort Review. Ann Blood Cancer. 2018;1(2):1006.