Ann Arthritis Clin Rheumatol | Volume 6, Issue 1 | Research Article | Open Access

Enhanced Mitochondrial Metabolism of Chondrocytes Promotes Diabetes with Osteoarthritis

Qing L^1#, Qiu D^2#, Shuangshuang L³ , Jian L³ , Simin L^2* and Qiping S^3*

¹ Department of Endocrinology, Dongguan Kuanghua Hospital, China ² Center for Bone and Joint and Sports Medicine, The First Affiliated Hospital of Jinan University, China ³ Department of Endocrinology, The First Affiliated Hospital of Jinan University, China

^*Correspondance to: Shi Qiping 

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Abstract

Objective: The study sought to explore the effect of blood glucose on the metabolism of chondrocytes. Methods: Chondrocytes from 7 patients, 2 from diabetes combined with KOA patients, 3 from simple KOA patients, 2 from femoral neck fracture without diabetes and KOA patients were extracted for metabolic analysis. Results: Glycolysis metabolism of chondrocytes in diabetes combined with KOA group was the strongest, followed by simple KOA group and normal chondrocytes, while mitochondrial metabolism was the weakest in diabetes combined with KOA group, followed by simple KOA group and normal chondrocytes. Conclusion: The decreased metabolism of mitochondria in chondrocytes leads to increased oxidative stress, which may be one of the promoting factors of diabetes complicated with osteoarthritis.

Keywords:

Cartilage cells; Osteoarthritis; Oxidative stress; Glucose metabolism

Citation:

Qing L, Qiu D, Shuangshuang L, Jian L, Simin L, Qiping S. Enhanced Mitochondrial Metabolism of Chondrocytes Promotes Diabetes with Osteoarthritis. Ann Arthritis Clin Rheumatol. 2023; 6(1): 1026..