Ann Arthritis Clin Rheumatol | Volume 3, Issue 2 | Case Report | Open Access

Lofgren’s Syndrome: A Rare Sarcoidosis Presentation in a Rural Hospital

Shiyu Wang1 and Shailendra Singh2*

1Deaprtment of Internal Medicine, White River Health System, USA
2Department of Rheumatology, White River Health System, Batesville, USA

*Correspondance to: Shailendra Singh 

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Lofgren’s syndrome is the most common presentation of acute sarcoid arthritis, it presents as a triad of hilar adenopathy, acute polyarthritis and erythema nodosum. Acute polyarthritis generally presents in <2 months and classically involves ankles bilaterally. Erythema nodosum is also classically present upon initial symptoms. Chest radiograph is needed to make a diagnosis of sarcoidosis and for confirmation of hilar adenopathy. Patient is a 43 year old man who was found to have bilateral ankle and left wrist swelling and pain, later found to have erythema nodosum and hilar lymphadenopathy. Initially started on ibuprofen with partial relief, and then started on oral prednisone with rapid symptomatic relief within 2 months of initiation and resolution of symptoms. This case highlights a typical course and workup of Lofgren’s syndrome and evidence guided treatment.


Lofgren’s syndrome; Hilar adenopathy; Polyarthritis; Sarcoidosis


Wang S, Singh S. Lofgren’s Syndrome: A Rare Sarcoidosis Presentation in a Rural Hospital. Ann Arthritis Clin Rheumatol. 2020; 3(2):1021.

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