Am J Otolaryngol Head Neck Surg | Volume 3, Issue 5 | Mini Review | Open Access

Recurrent Respiratory Papillomatosis: A Review

Guilherme Simas do Amaral Catani1*, Maria Eduarda Carvalho Catani2, Gabriela Alves Marroni1 and Larissa Molinari Madlum1

1Federal University of Paraná, Curitiba, Brazil
2UNIFEBE Medical School, Brusque, Brazil

*Correspondance to: Guilherme Simas do Amaral Catani 

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Recurrent  Respiratory  Papillomatosis  (RRP)  is  a  disease  of  exophytic  lesions  in  respiratory epithelium and vocal folds, being an important cause of childhood dysphonia. The etiology comes from the Human papillomavirus(HPV) which presents the host with high morbidity, in addition to being a precursor to neoplasms such as squamous cell carcinoma. The disease is more severe in its juvenile form, while in the adult form the disease occurs less frequently. Clinically it is pathology of  nonspecific  symptoms.  The  diagnosis  is  confirmed  by  laryngoscopy  and  the  treatment  has  as principles the control of the disease and keeping the patient's airway clear, since there is no cure until the present moment. Although surgery is the main form of disease control, adjuvant treatments with cidofovir and bevacizumab have shown a better prognosis for the disease. The HPV vaccine 
has also been related to therapeutic and prophylactic effects, resulting in a decrease in the number of procedures per year.


Recurrent respiratory papillomatosis; HPV; Cidofovir; Bevacizumab


do Amaral Catani GS, Carvalho Catani ME, Marroni GA, Madlum LM. Recurrent Respiratory Papillomatosis: A Review. Am J Otolaryngol Head Neck Surg. 2020;3(5):1104..

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