Guilherme Simas do Amaral Catani1*, Maria Eduarda Carvalho Catani2, Gabriela Alves Marroni1 and Larissa Molinari Madlum1
1Federal University of Paraná, Curitiba, Brazil
2UNIFEBE Medical School, Brusque, Brazil
Recurrent Respiratory Papillomatosis (RRP) is a disease of exophytic lesions in respiratory epithelium and vocal folds, being an important cause of childhood dysphonia. The etiology comes from the Human papillomavirus(HPV) which presents the host with high morbidity, in addition to being a precursor to neoplasms such as squamous cell carcinoma. The disease is more severe in its juvenile form, while in the adult form the disease occurs less frequently. Clinically it is pathology of nonspecific symptoms. The diagnosis is confirmed by laryngoscopy and the treatment has as principles the control of the disease and keeping the patient's airway clear, since there is no cure until the present moment. Although surgery is the main form of disease control, adjuvant treatments with cidofovir and bevacizumab have shown a better prognosis for the disease. The HPV vaccine
has also been related to therapeutic and prophylactic effects, resulting in a decrease in the number of procedures per year.
Recurrent respiratory papillomatosis; HPV; Cidofovir; Bevacizumab
do Amaral Catani GS, Carvalho Catani ME, Marroni GA, Madlum LM. Recurrent Respiratory Papillomatosis: A Review. Am J Otolaryngol Head Neck Surg. 2020;3(5):1104..