Am J Otolaryngol Head Neck Surg | Volume 3, Issue 6 | Research Article | Open Access

Age is Unrelated to Hyposmia Onset or Its Treatment with Intranasal Theophylline

Robert I Henkin* and Mona Abdelmeguid

Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, USA

*Correspondance to: Robert I Henkin 

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Purpose: We recently demonstrated the efficacy of intranasal Theophylline in the treatment of smell dysfunction in a large, diverse group of patients who exhibited this abnormality. Because age has been reported to be a factor in Hyposmia onset in the general population it was of interest to evaluate Hyposmia and age in a patient group who exhibited Hyposmia before and after treatment with intranasal Theophylline. Methods: Ninety-four patients with smell dysfunction were studied. Of these patients, 43 were <65 years of age whereas 51 were >65 years of age. All patients were initially studied without treatment. They were then treated with intranasal delivery of 20 μg Theophylline twice into each nostril once daily for two-12 months. Subjective responses, olfactometry, and gustometry were obtained before and after treatment. Results: Smell loss was similar in both patient groups prior to treatment: Smell function was significantly impaired compared to normal subjects. After treatment Hyposmia improved in both groups to the same degree with acuity returning toward or to the normal range in both patient groups. Conclusion: These results indicate that Hyposmia is of similar magnitude in patients age 65 prior to any treatment and that after treatment with intranasal Theophylline acuity is of similar efficacy in patients 65 years of age indicating that age is not a factor either in onset or inability to correct Hyposmia.


Hyposmia; Smell loss; Taste loss; Flavor loss; Theophylline


Henkin RI, Abdelmeguid M. Age is Unrelated to Hyposmia Onset or Its Treatment with Intranasal Theophylline. Am J Otolaryngol Head Neck Surg. 2020;3(3):1091.

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