Am J Otolaryngol Head Neck Surg | Volume 1, Issue 4 | Research Article | Open Access
Takanosawa M, Nagatomo T, Nishino H* and Yamauchi T
Department of Otolaryngology-Head and Neck Surgery, Jichi Medical University, Japan
*Correspondance to: Hiroshi Nishino
Fulltext PDFObjective: To report the results of endoscopic endonasal surgery with segmental resection followed by postoperative radiation for T3/T4aN0M0 nasal mucosal malignant melanoma, and to identify future issues in the treatment of nasal mucosal malignant melanoma.
Methods: This was a retrospective study in one institute. Six patients with T3/T4aN0M0 nasal malignant mucosal melanoma between March 2009 and June 2013 were analyzed. A surgical procedure, endoscopic endonasal surgery with segmental resection, with curative intent was performed that was followed by postoperative radiation.
Results: Two patients were alive without disease. One patient had local recurrence and was salvaged by resection. The other three patients had distant metastases. Aggressive treatments that consisted of surgery, irradiation, chemotherapy, and nivolumab administration for distant metastases were performed. Median disease-free survival was 1017 days (207 to 2807 days), and median overall survival was 1754 days (207 to 2807 days).
Conclusion: Endoscopic endonasal segmental resection with minimum safety margins that was followed by postoperative radiation produced good local control. Despite distant metastases, aggressive treatments for distant metastases may provide good overall survival rates. Endoscopic endonasal segmental resection followed by postoperative irradiation is useful for nasal malignant melanoma.
Endoscopic endonasal surgery; Segmental resection; Postoperative radiation; Nasal mucosal malignant melanoma
Takanosawa M, Nagatomo T, Nishino H, Yamauchi T. Endoscopic Surgery Followed by Postoperative Radiation for T3/T4a Nasal Malignant Mucosal Melanoma. Am J Otolaryngol Head Neck Surg. 2018;1(4):1020.