Ekun OE1, Abajingin DD2 and Olusola AO1*
1Department of Biochemistry, Adekunle Ajasin University, Nigeria
2Department of Physics and Electronics, Adekunle Ajasin University, Nigeria
There is increasing interest in the exploration of static and alternating magnetic fields in the treatment of several diseases. Malaria is a devastating zoonotic disease that is capable of causing multi-organ damage in its advanced stages. The mobilization of lipids in cardiac tissue can lead to atherosclerosis, and consequent myocardial infarction, just as elevated kidney biomarkers can suggest kidney malfunction. This study sought to examine the effects of alternating magnetic fields on cardiac lipid profile and renal function in mice model of malaria. Mice were obtained and divided into six (6) groups, such that groups I to V comprised seven mice each, parasitized with Plasmodium berghei and exposed to 10, 15, 20, 30 and 40 mT of alternating magnetic field. Group VI served as the control group, which was neither parasitized nor exposed to alternating magnetic field. After exposure for seven days, the mice were sacrificed and their organs were collected. Biochemical assays carried out on mice heart were the determination of total cholesterol, triglycerides, and High- Density Lipoprotein (HDL). Kidney function indices were also determined which included the determination of urea and creatinine. Results revealed that the levels of triglycerides decreased with increasing magnitude of the alternating magnetic field, with an attendant increase in HDL levels, which was comparable to control. In addition, there were reductions in urea levels as magnetic field intensity increased, whereas creatinine levels increased with increasing intensity of alternating magnetic when compared to control. It is concluded that the exposure of Plasmodium-infected mice to alternating magnetic field could prove to becoming a viable alternative in preventing tissue damage in malaria therapy.
Plasmodium berghei; Magnetic field; Cardiac function; Lipid profile; Kidney function
Ekun OE, Abajingin DD, Olusola AO. Effects of Alternating Magnetic Field Exposure on Cardiac Lipid Profile and Renal Function of Mice Infected with Plasmodium berghei. Am J Med Public Health. 2023; 4(4): 1054..