Division of Biology/ Biochemistry, University of Orléans, 556 rue Isabelle Romée, 45640 Sandillon, FranceFulltext PDF
It was shown 32 years ago that the sea star Axial Organ cells (AO cells) produced a spontaneous cytotoxicity against mouse cancerous cells. Recently, we discovered a sea star Igkappa gene with immune properties. This gene was inserted in a CMV (Cytomegalovirus) and finally in a plasmid called «young» plasmid. The induced «young» protein exerted a spontaneous cytotoxicity against osteosarcoma cells (U2OS cells) against A-375 melanoma cells and HeLa cells.
Leclerc M. The Sea Star Igkappa Gene: Effects against Human Melanoma Cells (A-375) Osteosarcoma Cells (U2OSCells) and HeLa Cells - Preliminary Study. Am J Cancer Res Ther. 2020;1(1): 1001..